Ambulant myocardial ischemia and its prognostic implications.

Anti-ischemic therapy and stress testing: pathophysiologic, diagnostic and prognostic implications

Anti-ischemic therapy, in particular beta-blockers, is the most commonly employed drug for the control of myocardial ischemia in patients with stable coronary artery disease. Its widespread use also in patients with suspected coronary artery disease has important practical, clinical diagnostic and prognostic implications because diagnostic tests are heavily influenced by its effects. In the pre...

Sudden versus gradual withdrawal of sotalol in ambulant patients with ischaemic heart disease.

Imaging as an End Point in Ischemia Trials

Imaging of cardiac function and anatomy has advanced at an exponential rate over the past two decades. Our ability to quantitatively assess the degree of myocardial ischemia and accurately define the vascular anatomy using noninvasive techniques is greater than ever before. Current advances is cardiac imaging are allowing us to more safely assess patients for myocardial ischemia and better unde...

No-reflow phenomenon in patients with acute myocardial infarction: its pathophysiology and clinical implications.

For patients with acute myocardial infarction (MI), the immediate therapeutic goal is to establish the patency of the infarct-related artery. Prolonged myocardial ischemia, however, often breaks down the coronary microvasculature, and the flow to the infarct myocardium may be markedly reduced. This is called the no-reflow phenomenon. This phenomenon is important not solely because it correlates...

The detection of silent ischemia: cautions and precautions.

THERE IS NOW convincing evidence that myocardial ischemia may occur in the absence of symptoms.' This phenomenon, which has acquired the label "silent ischemia," is receiving considerable attention as a factor with potential prognostic significance in the management of coronary artery disease. Basic to an understanding of silent ischemia, its prevalence, precipitating factors, significance as a...